Design and exploitation of novel dendritic phytoglycogen based nanocomplexes for delivery of natural antimicrobial compounds for food safety applications
Digital Document
Document
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http://hdl.handle.net/11134/20002:860660184
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Persons
Creator (cre): Xue, Jingyi
Major Advisor (mja): Luo, Yangchao
Associate Advisor (asa): Blesso, Christopher
Associate Advisor (asa): Fernandez, Maria Luz
Associate Advisor (asa): He, Jie
Associate Advisor (asa): Lei, Yu
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Title |
Title
Title
Design and exploitation of novel dendritic phytoglycogen based nanocomplexes for delivery of natural antimicrobial compounds for food safety applications
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Origin Information
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Parent Item
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Digital Origin |
Digital Origin
born digital
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Description |
Description
Phytoglycogen (PG) is a naturally occurring glycogen-like water soluble carbohydrate with nanoscale spherical structure existing in the endosperm of sugary mutant grains. While its unique dendritic nanostructures offer promising structural features to harbor bioactive compounds, the strong hydrophilicity limits its applications for encapsulating lipophilic molecules. In this project, two strategies were applied on this dendritic polysaccharide to alter its physicochemical properties, enhance its encapsulation efficacy, and expand its applications in the fields of food safety and quantity management. First of all, the extracted PG was modified with various hydrophobic chains through gentle esterification and the obtained conjugates, which possessed different level of hydrophobicity, were exploited as carrier for bioactive compounds (curcumin) via a pH- driven method without the utilization of organic solvent or synthetic chemicals. Secondly, the hydrophobic PG nanoparticles were cooperated with the hydrolysate of zein, a prolamin extracted from corn, via a pH- and heating induced process with simultaneous deposition of lipophilic bioactive compounds (eugenol and thymol) on/inside of the dendritic structure without compromising their beneficial functionalities. The major objectives of this dissertation were to 1) develop a simple and eco-friendly extraction method; 2) modify PG with hydrophobic chains and compare the efficiency of different encapsulation methods; 3) design dendritic nanocomplexes via supramolecular interactions between modified PG and other food biopolymers for encapsulation of natural antimicrobial compounds; 4) explore the practical applications of obtained nanocomplexes in the preservation of fresh produce by inhibiting bacterial growth and biofilm formation. To sum up, the as-prepared nanocomplexes demonstrate superior physicochemical properties and functionalities for delivery of antimicrobial compounds with potent bactericidal activities, opening up new avenues for nanotechnology-enabled approaches to ensure food safety and quality.
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Genre
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Organizations
Degree granting institution (dgg): University of Connecticut
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Use and Reproduction |
Use and Reproduction
These Materials are provided for educational and research purposes only.
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Note |
Note
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Degree Name |
Degree Name
Doctor of Philosophy
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Degree Level |
Degree Level
Doctoral
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Degree Discipline |
Degree Discipline
Nutritional Science
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Local Identifier |
Local Identifier
S_20962856
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