Margination and Transport of Particles in Blood Flow
Digital Document
Document
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Handle
http://hdl.handle.net/11134/20002:860653131
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Persons |
Persons
Creator (cre): Carboni, Erik J.
Major Advisor (mja): Ma, Anson
Associate Advisor (asa): Shor, Leslie
Associate Advisor (asa): McCutcheon, Jeffrey
Associate Advisor (asa): Lu, Xiuling
Associate Advisor (asa): Torti, Suzy
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Title |
Title
Title Non-Sort
The
Title
Margination and Transport of Particles in Blood Flow
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Origin Information |
Origin Information
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Parent Item
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Resource Type
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Digital Origin |
Digital Origin
born digital
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Description |
Description
In blood flow in smaller blood vessels, red blood cells form a central core of flow and gives rise to a phenomenon known as margination. Margination is defined as the movement of a particle towards the periphery of blood vessels in blood flow. The margination of drug carriers, in particular, is desirable for the treatment of diseases because particles that exhibit marginating behavior are easier to diffuse into and/or target disease sites and deliver their drug payload. Experimentally, almost all existing studies of particle margination use particle adhesion as a mechanism for quantifying the margination propensity of particles. However, particle adhesion does not necessarily translate to margination and is affected by a number of other factors, limiting the conclusions that can be drawn from the results of these studies. This research investigates the margination of particles under various conditions via the use of direct particle tracking and without the limitations of an adhesion mechanism. Particle size, flow rate and margination distance were first investigated, finding that margination tends to increase with increasing particle size and with increasing flow rate. Furthermore, it was observed that smaller particles appear to require less channel length in the flow direction before significant margination was observed. Lastly, experimental evidence of larger margination velocities in blood were found, supporting modeling studies that suggest that particle-red blood cell interactions are largely responsible for margination. An interesting observation during this study was that the particle distribution after the channel constricted to its normal length from the inlet reservoir seemed to affect the margination of particles. A follow-up study of the effects of constrictions on margination was begun, with applications to the treatment of arteriolosclerosis. In this study, the percent occlusion, length and eccentricity of a constriction and expansion region were all varied. Increasing percent occlusion and constriction length were each found to increase margination. A decreasing eccentricity, signifying a more gradual constriction entrance, was found to lead to decreasing margination except for the case of a sudden constriction/expansion geometry which also exhibited low margination. The presence of a constriction led to enhanced margination with the presence of an expansion resulting in the opposite. In the final part of this work, pulsatile flow was investigated. Margination in both steady and pulsatile flow was compared and no significant difference was found. Further, the wait time between pulses was varied and no difference in margination was observed. However, the variation of the amplitude of the pulsatile flow did display increasing margination with increasing amplitude, in line with the flow rate observations from the first experimental study.
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Genre
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Organizations |
Organizations
Degree granting institution (dgg): University of Connecticut
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Rights Statement |
Rights Statement
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Use and Reproduction |
Use and Reproduction
These materials are provided for educational and research purposes only.
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Local Identifier |
Local Identifier
OC_d_1581
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